The big advantage of wood, besides being available at any lumber yard, is that it is lightweight. Most substitutes (starboard, etc.) are a lot heavier.
I have had reasonable luck using marine grade ply (available anywhere in FL) protected with WEST brand epoxy. Putting a single 6 oz. glass cloth, soaked in epoxy, on the upper surface makes it pretty indestructable and gives a nice finish.
Polyester resins are not waterproof, and do not protect as well as epoxy.
It is best to have all the panels in a boat removeable, you need to be able to get anywhere. I say this with authority: the previous owner installed a beautiful but permanent glass/foam sandwich in my cockpit, and I have to cut a hatch every time I need access...
1975 32' Flybridge Sedan, twin Perkins 6-354 diesels, 1:1.53 velvetdrives, 16 X 19 props. Merritt Island, Florida